Hydrazine hydrate (1:1) → HCID 21488669, compound

HRID 1974158Notes

Reaction equation

HRID 1974158 reaction equation
Cl[C:2]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:19])[CH:8]=2)[N:3]=1.O.[NH2:21][NH2:22]>>[Cl:19][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH:21][NH2:22])[CH:11]=[C:10]2[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21488657HCID 21488657, compound

Product 1

HCID 21488669HCID 21488669, compound

Procedure

In the manner given in Example 1, 2,6-dichloro-4-(o-fluorophenyl)quinoline is reacted with hydrazine hydrate at reflux to give 6-chloro-4-(o-fluorophenyl)-2-hydrazinoquinoline.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-537ee2554af745d1901d502a272c12ff
Source dataset
uspto-grants-1976_12
Patent number
US04000153

Reaction notes

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