HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 5-(N,N-Dibenzylglycyl)-2-(3-hydroxypropoxy)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Chloro-1-propanol | HCID 12313 | — |
| Reactant | 5-((Bis(benzyl)amino)acetyl)salicylamide | HCID 121727 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 5-(N,N-Dibenzylglycyl)-2-(3-hydroxypropoxy)benzamide | HCID 21488935 | 132.5% |
Reaction Steps
A mixture of 5-(N,N-dibenzylglycyl)salicylamide (10.0 g), sodium iodide (4.0 g), potassium carbonate (3.7 g) and 3-chloropropan-1-ol (2.56 g) in butanone (100 ml) was heated under reflux for 24 hours, and filtered to give a cream solid (15.3 g). This was extracted with boiling ethanol and the clear solution was cooled to give a yellow solid (4.0 g) which was crystallised from methanol as colourless crystals (3.4 g). It had m.p. 171°-175°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000193 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-39244b7a906f43bd8e9c14b1ea7295d7 |
| Source note | uspto-grants-1976_12 |