反应详情

A mixture of 5-(N,N-dibenzylglycyl)salicylamide (10.0 g), sodium iodide (4.0 g), potassium carbonate (3.7 g) and 3-chloropropan-1-ol (2.56 g) in butanone (100 ml) was heated under reflux for 24 hours, and filtered to give a cream solid (15.3 g). This was extracted with boiling ethanol and the clear solution was cooled to give a yellow solid (4.0 g) which was crystallised from methanol as colourless crystals (3.4 g). It had m.p. 171°-175°.

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. filtrationfiltered