HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-tert-BUTYLAMINO-5,7-DINITRO-2-TRIFLUOROMETHYLBENZIMIDAZOLE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-5,7-dinitro-2-trifluoromethylbenzimidazole | HCID 135677577 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-tert-BUTYLAMINO-5,7-DINITRO-2-TRIFLUOROMETHYLBENZIMIDAZOLE | HCID 135677575 | — |
Reaction Steps
4-Chloro-5,7-dinitro-2-trifluoromethylbenzimidazole (5.0 grams) was mixed with 1.6 grams of triethylamine and 1.2 grams of tert-butylamine in a small amount of ethanol. The resulting reaction mixture was refluxed over a weekend, then poured into water and the resulting aqueous mixture acidified and filtered to separate the expected 4-tert-butylamino-5,7-dinitro-2-trifluoromethylbenzimidazole product. It was recrystallized from ethanol as an orange solid, m.p., 195°-97° C. Elemental analysis confirmed the identity of the product. A second crop melted at 177°-88° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000295 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-19368ad923994039bfe5a79c863c667f |
| Source note | uspto-grants-1976_12 |