反应详情

4-Chloro-5,7-dinitro-2-trifluoromethylbenzimidazole (5.0 grams) was mixed with 1.6 grams of triethylamine and 1.2 grams of tert-butylamine in a small amount of ethanol. The resulting reaction mixture was refluxed over a weekend, then poured into water and the resulting aqueous mixture acidified and filtered to separate the expected 4-tert-butylamino-5,7-dinitro-2-trifluoromethylbenzimidazole product. It was recrystallized from ethanol as an orange solid, m.p., 195°-97° C. Elemental analysis confirmed the identity of the product. A second crop melted at 177°-88° C.

1. customThe resulting reaction mixture
2. temperaturewas refluxed over a weekend
3. filtrationfiltered
4. customto separate the expected 4-tert-butylamino-5,7-dinitro-2-trifluoromethylbenzimidazole product
5. customIt was recrystallized from ethanol as an orange solid
6. custom195°-97° C