Hydrochloric Acid → HCID 21489488, compound

HRID 1974370Notes

Reaction equation

HRID 1974370 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[C:20]3[N:19]=[C:18]4[CH2:21][CH2:22][CH2:23][N:17]4[CH:16]=[CH:15][C:14]=3[CH:13]=[CH:12][CH2:11]2)=[CH:2]1.[ClH:24]>C(O)C>[ClH:24].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[C:20]3[N:19]=[C:18]4[CH2:21][CH2:22][CH2:23][N:17]4[CH:16]=[CH:15][C:14]=3[CH:13]=[CH:12][CH2:11]2)=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21489485HCID 21489485, compound

Product 1

HCID 21489488HCID 21489488, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A portion of the product of Example 3, 12 g., is suspended in 150 ml. of absolute ethanol and treated with one chemical equivalent of 5.02 N ethanolic hydrogen chloride. A clear solution results which is diluted with 200 ml. of anhydrous ether resulting in precipitation of the desired hydrochloride salt. The salt is collected on a filter and recrystallized from a mixture of 150 ml. of ethanol and 150 ml. of ether, yielding 9.3 g. (69.1%) of pure product, m.p. 262°-264° C.

Workup

  1. customA clear solution results which
  2. additionis diluted with 200 ml
  3. customof anhydrous ether resulting in precipitation of the desired hydrochloride salt
  4. customThe salt is collected on
  5. filtrationa filter
  6. customrecrystallized from a mixture of 150 ml
  7. customof ether, yielding 9.3 g

Sources & evidence

ORD record
ord-43890042c1874fe6a5e9ca9ab9c72b30
Source dataset
uspto-grants-1976_12
Patent number
US04000304

Reaction notes

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