反应详情

The material given in Example 1 was prepared in accordance with the following. 20.0 g. of N,N-dibenzyl-2-chloroethylamine hydrochloride and 27.6 g of potassium carbonate were mixed in 250 ml of acetonitrile. The mixture was refluxed for 15 min. and 13.8 g of 4-benzyloxyphenol were added, whereupon the mixture was refluxed for 5 hours while stirred. After filtration and evaporation the residue was recrystallized from petroleum ether. 18.4 g of 1-(N,N-dibenzylamino)-2-(4-benzyloxyphenoxy)-ethane was obtained. The structure was determined using NMR.

1. customwas prepared in accordance with the following
2. temperatureThe mixture was refluxed for 15 min.
3. temperaturewas refluxed for 5 hours
4. filtrationAfter filtration and evaporation the residue
5. customwas recrystallized from petroleum ether