反应详情

温度

180 °C

A mixture of 5-chloro-2,3-dihydroxypyridine (1.0g.) and phosphoryl chloride (10ml.) was heated overnight at 180° C. in a sealed tube. The phosphoryl chloride was distilled off, and the residue was chromatographed, to give 2,5-dichloro-3-hydroxypyridine, m.p. 160°-161° C. (ethyl acetate - petrol).

1. distillationThe phosphoryl chloride was distilled off
2. customthe residue was chromatographed