反应详情

(i) A solution of 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole (6.9 g) and ethyl isothiocyanate (3.84 g) in ethanol was heated under reflux for 2 hours. Concentration followed by recrystallisation of the residue from aqueous ethanol gave N-ethyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea (9.0 g), m.p. 140°-141°.

1. temperatureunder reflux for 2 hours
2. concentrationConcentration
3. customfollowed by recrystallisation of the residue from aqueous ethanol