Methylamine → HCID 19101480, compound

HRID 1974431Notes

Reaction equation

HRID 1974431 reaction equation
[CH3:1][NH2:2].Cl[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13].[OH-].[Na+]>O>[CH3:1][NH:2][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

Participants

5

Reactant 3

HCID 6329Methylamine2×HCID 14798Sodium HydroxideHCID 30849741-Nonanol, 9-chloro-

Product 1

HCID 19101480HCID 19101480, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

400 g a 40% aqueous solution of methylamine and 180 g of 9-chlorononanol were introduced into an autoclave equipped with a stirrer, a thermometer and a pressure pump and heated to 100° C. At the temperature, 93 g of a 48% aqueous solution of sodium hydroxide was forcedly introduced to the autoclave over 6 hours and the resulting mixture was aged for 1 hours. After cooling, the content was taken out from the autoclave and unreacted methylamine and water were removed therefrom under reduced pressure. Then, ethanol was added thereto and sodium chloride thus precipitated was filtered off. Ethanol was distilled off from the filtrate and the resulting solution was further subjected to distillation to give 125 g of 9-(N-methylamino)nonanol.

Workup

  1. customequipped with a stirrer
  2. temperatureAfter cooling
  3. customwere removed
  4. additionThen, ethanol was added
  5. customsodium chloride thus precipitated
  6. filtrationwas filtered off
  7. distillationEthanol was distilled off from the filtrate
  8. distillationthe resulting solution was further subjected to distillation

Sources & evidence

ORD record
ord-426abac6664346d6b4fd864a7f287fac
Source dataset
uspto-grants-1994_02
Patent number
US05282983

Reaction notes

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