2-Methylimidazole → HCID 178432464, compound

HRID 1974481Notes

Reaction equation

HRID 1974481 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5]2.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>CN(C=O)C>[CH3:17][C:18]1[NH:19][CH:20]=[C:21]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[C:6](=[O:16])[NH:5]3)[N:22]=1

Participants

4

Reactant 2

HCID 127492-MethylimidazoleHCID 99912306-Fluoro-7-nitro-1,4-dihydroquinoxaline-2,3-dione

Product 1

HCID 178432464HCID 178432464, compoundYield 42.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

In DMF, 1 g of 6-fluoro-7-nitroquinoxaline-2,3-(1H,4H)-dione and 1.8 g of 2-methylimidazole were stirred with heating at 130° C. for 8 hours. The reaction mixture was then concentrated and diluted with water, whereupon crystals separated out. The crystals were recrystallized from DMF-water to provide 540 mg of 6-(2-methylimidazolyl)-7-nitroquinoxaline-2,3-(1H,4H)-dione.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. additiondiluted with water, whereupon crystals
  3. customseparated out
  4. customThe crystals were recrystallized from DMF-water

Sources & evidence

ORD record
ord-0b488c1a54a64c228ff99cc9cbf4bef8
Source dataset
uspto-grants-1994_02
Patent number
US05283244

Reaction notes

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