反应详情

A mixture of 2-[1-(3-hydroxyphenyl)-1-methoxypropyl]thiazole (31 g), 2-propynyl bromide (80% solution in toluene, 48.1 ml), potassium carbonate (48 g) and acetone (375 ml) was stirred and heated to reflux for 17 hours. The mixture was filtered and the filtrate was evaporated. The residue was partitioned between diethyl ether and water and the organic layer was washed with water, dried (MgSO4) and evaporated. The residue was purified by chromatography eluting with hexane/ethyl acetate (1:1 v/v) to give 2-[1-(3-(2-propynyloxy)phenyl)-1-methoxypropyl]thiazole as an oil (34 g, 94%).

1. temperatureheated
2. temperatureto reflux for 17 hours
3. filtrationThe mixture was filtered
4. customthe filtrate was evaporated
5. customThe residue was partitioned between diethyl ether and water
6. washthe organic layer was washed with water
7. dry with materialdried (MgSO4)
8. customevaporated
9. customThe residue was purified by chromatography
10. washeluting with hexane/ethyl acetate (1:1 v/v)