反应详情

5'-Chloro-N-ethyl-4'-fluoro-2'-nitroacetanilide (74 g, 0.284 mmol) is treated with N-methylpiperazine (126 ml, 1.13 mol) and the solution obtained is stirred at 60° for 2 hours. The reaction mixture is evaporated, the residue is dissolved in ethyl acetate (250 ml) and washed in succession with water (3×100 ml) and 10 percent sodium chloride solution (100 ml). The organic solution is dried over magnesium sulfate and evaporated. The residue is recrystallized from ethyl acetate/n-hexane. There are obtained 72.3 g (78.5%) of N-ethyl-4'-fluoro-5'-(4-methyl-1-piperazinyl)-2'-nitroacetanilide with a m.p. of 117°-119°.

1. customthe solution obtained
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved in ethyl acetate (250 ml)
4. washwashed in succession with water (3×100 ml) and 10 percent sodium chloride solution (100 ml)
5. dry with materialThe organic solution is dried over magnesium sulfate
6. customevaporated
7. customThe residue is recrystallized from ethyl acetate/n-hexane