Water → HCID 23233629, compound

HRID 1974784Notes

Reaction equation

HRID 1974784 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[NH2:17].O.[OH-].[Na+]>C1(C)C=CC=CC=1>[NH2:17][C:3]1[CH:4]=[C:5]([N:8]([C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16])[CH:6]=[CH:7][CH:2]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 856445504-chloro-3-amino-N,N-bistrifluoromethyl-aminobenzene

Product 1

HCID 23233629HCID 23233629, compoundYield 44.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

26.5 g of 4-chloro-3-amino-N,N-bistrifluoromethyl-aminobenzene were dissolved in 50 g of toluene and reacted at 350° C. The reaction products were introduced into 150 ml of water. The two-phase mixture obtained was made alkaline with 20% strength by weight aqueous sodium hydroxide solution, and the toluene phase was separated off, to give 10.3 g of 3-amino-N,N-bistrifluoromethyl-aminobenzene of boiling point 76° to 78° C. at 20 mbar by distillation.

Workup

  1. customreacted at 350° C
  2. customThe two-phase mixture obtained
  3. customthe toluene phase was separated off

Sources & evidence

ORD record
ord-6081a649b3114deea9542357fd8c9758
Source dataset
uspto-grants-1994_02
Patent number
US05283378

Reaction notes

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