Hydrochloric Acid → HCID 19100372, compound

HRID 1974801Notes

Reaction equation

HRID 1974801 reaction equation
[OH-].[K+].C(O)C.C[O:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:17][C:18]3[CH:24]=[C:23]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:22]=[CH:21][C:19]=3[N:20]=2)=[CH:12][CH:11]=1)=[O:9].Cl>O>[C:8]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:17][C:18]3[CH:24]=[C:23]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:22]=[CH:21][C:19]=3[N:20]=2)=[CH:12][CH:11]=1)([OH:9])=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 19100365HCID 19100365, compound

Product 1

HCID 19100372HCID 19100372, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To 0.76 g (11.5 mM) of 85%-potassium hydroxide, 50 ml of ethanol was added, followed by stirring at 65° C. and dissolving. To the resultant solution, 1.80 g (4.72 mM) of 2-(p-methoxycarbonylphenyl)-6-octylbenzothiazole was added, followed by stirring for 20 minutes at 65° C. After the reaction, the reaction mixture was poured into water and 1.5 ml of concentrated hydrochloric acid was added thereto to precipitate a crystal. The crystal was recovered by filtration and sufficiently washed with water, followed by drying to obtain 1.66 g of 2-(p-carboxyphenyl)-6-octylbenzothiazole (Yield: 95.7%).

Workup

  1. dissolutiondissolving
  2. stirringby stirring for 20 minutes at 65° C
  3. customAfter the reaction
  4. additionwas added
  5. customto precipitate a crystal
  6. filtrationThe crystal was recovered by filtration
  7. washsufficiently washed with water
  8. customby drying

Sources & evidence

ORD record
ord-829d806954d34a8bad35749f273b3324
Source dataset
uspto-grants-1994_02
Patent number
US05284599

Reaction notes

Loading…