HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 4-Hydrazino-2-(trifluoromethyl)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-chloro-2-(trifluoromethyl)quinazoline | HCID 1475435 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Hydrazino-2-(trifluoromethyl)quinazoline | HCID 1475464 | — |
Reaction Steps
4-Chloro-2-trifluoromethylquinazoline (46.4 g, 0.2 mole) was taken up in ethanol (500 ml). Hydrazine hydrate (20 ml, 0.4 mole) was added and the contents refluxed for 2 hours. On cooling, the yellow precipitate was filtered and slurried in water (500 ml) to removed hydrazine hydrochloride. Filtration gave the product as a yellow crystalline solid, 34.5 g (76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284739 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-660c1964dfcd4fa88cf7408a28da8c43 |
| Source note | uspto-grants-1994_02 |