反应详情

4-Chloro-2-trifluoromethylquinazoline (46.4 g, 0.2 mole) was taken up in ethanol (500 ml). Hydrazine hydrate (20 ml, 0.4 mole) was added and the contents refluxed for 2 hours. On cooling, the yellow precipitate was filtered and slurried in water (500 ml) to removed hydrazine hydrochloride. Filtration gave the product as a yellow crystalline solid, 34.5 g (76%).

1. temperaturethe contents refluxed for 2 hours
2. temperatureOn cooling
3. filtrationthe yellow precipitate was filtered
4. customto removed hydrazine hydrochloride
5. filtrationFiltration