反应详情

1 g of 6-cyano-2,2-dimethyl-3,4-epoxychromane and 1 g of 3-hydroxypyridazine are refluxed for 20 hours in 5 ml of dioxane, in the presence of 0.20 ml of a methanolic solution containing 35% of benzyltrimethylammonium hydroxide. The mixture is concentrated under vacuum and the residue is then triturated in 20 ml of water; the precipitate obtained is filtered off, washed with water and isopropyl ether and then recrystallized from 10 ml of isopropyl alcohol to give 0.9 g of the expected product.

1. concentrationThe mixture is concentrated under vacuum
2. customthe residue is then triturated in 20 ml of water
3. customthe precipitate obtained
4. filtrationis filtered off
5. washwashed with water and isopropyl ether
6. customrecrystallized from 10 ml of isopropyl alcohol