Benzyltrimethylammonium hydroxide → HCID 178431171, compound

HRID 1974838Notes

Reaction equation

HRID 1974838 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8]([CH3:14])([CH3:13])[CH:7]1[O:15][CH:6]21)#[N:2].[OH:16][C:17]1[N:18]=[N:19][C:20]([OH:23])=[CH:21][CH:22]=1.[OH-].C([N+](C)(C)C)C1C=CC=CC=1>O1CCOCC1.CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[O:9][C:8]([CH3:14])([CH3:13])[C@@H:7]([OH:15])[C@@H:6]2[N:18]1[C:17](=[O:16])[CH:22]=[CH:21][C:20]([OH:23])=[N:19]1)#[N:2]

Participants

6

Reactant 3

HCID 66854Benzyltrimethylammonium hydroxideHCID 108673602,2-Dimethyl-3,4-epoxy-6-cyanochromanHCID 178516298pyridazine-3,6-diol

Product 1

HCID 178431171HCID 178431171, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture containing I g of 6-cyano-2,2-dimethyl-3,4-epoxychromane, 1.1 g of 3,6-dihydroxypyridazine and 0.20 ml of a methanolic solution containing 357. of benzyltrimethylammonium hydroxide, in 5 ml of dioxane and 5 ml of dimethylformamide, is refluxed for 50 hours. It is concentrated under vacuum and the residue is then triturated in 15 ml of water. The precipitate formed is filtered off and washed with water and then isopropyl ether.

Workup

  1. additionA mixture containing I
  2. additioncontaining 357
  3. concentrationIt is concentrated under vacuum
  4. customthe residue is then triturated in 15 ml of water
  5. customThe precipitate formed
  6. filtrationis filtered off
  7. washwashed with water

Sources & evidence

ORD record
ord-a6c6c7b0547e4f24be8d679e7956864c
Source dataset
uspto-grants-1994_02
Patent number
US05284838

Reaction notes

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