反应详情

3 g (13.9 mmol) of ethyl 4-hydroxy-4-methylaminomethylpiperidine-1-carboxylate are heated overnight under reflux with 30 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are stirred with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

1. concentrationThe product is concentrated
2. filtrationfiltered off with suction
3. dry with materialdried in a vacuum desiccator over P4O10