Hydrochloric Acid → 4-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

HRID 1974872Notes

Reaction equation

HRID 1974872 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:3].[ClH:17]>>[ClH:17].[ClH:17].[CH3:3][N:2]([CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19382159HCID 19382159, compound

Product 1

HCID 193822164-((Dimethylamino)methyl)-4-piperidinol dihydrochloride

Procedure

4.5 g (19.4 mmol) of ethyl 4-dimethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record
ord-09706ab2dac248c9b2ece0af30bd9028
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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