Hydrochloric Acid → 4-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

HRID 1974874Notes

Reaction equation

HRID 1974874 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:10][CH2:9][N:8](C(OCC)=O)[CH2:7][CH2:6]1)[CH3:2].[ClH:17]>>[ClH:17].[ClH:17].[CH2:1]([NH:3][CH2:4][C:5]1([OH:16])[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1)[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19382186HCID 19382186, compound

Product 1

HCID 193821764-Ethylaminomethyl-4-hydroxypiperidine dihydrochloride

Procedure

4.6 g (20 mmol) of ethyl 4-ethylaminomethyl-4-hydroxypiperidine-1-carboxylate are heated overnight under reflux with 35 ml of concentrated hydrochloric acid. The product is concentrated, and the crystals are triturated with acetone, filtered off with suction and dried in a vacuum desiccator over P4O10.

Workup

  1. concentrationThe product is concentrated
  2. customthe crystals are triturated with acetone
  3. filtrationfiltered off with suction
  4. dry with materialdried in a vacuum desiccator over P4O10

Sources & evidence

ORD record
ord-93982687ac3944f6ae6d8df8e0edbe16
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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