Dimethylamine → 3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

HRID 1974875Notes

Reaction equation

HRID 1974875 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][N:16]([CH3:17])[CH3:15])([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 145784553-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

Procedure

9.6 g (50 mmol) of 5-benzyl-5-aza-1-oxaspiro[2,4]heptane are added dropwise to 50 ml of dimethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.

Workup

  1. concentrationThe batch is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-3e8b83bf3e8c4926b150b61d4988bc0f
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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