3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol → 3-((Dimethylamino)methyl)pyrrolidin-3-ol

HRID 1974876Notes

Reaction equation

HRID 1974876 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:14][N:15]([CH3:17])[CH3:16])([OH:13])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:16][N:15]([CH2:14][C:10]1([OH:13])[CH2:11][CH2:12][NH:8][CH2:9]1)[CH3:17]

Participants

4

Reactant 1

HCID 145784553-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

Product 1

HCID 145784593-((Dimethylamino)methyl)pyrrolidin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

9.4 g (39 mmol) of 1-benzyl-3-dimethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (5%) at 100° C. and 90 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. customat 100° C.
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-583891d993f14894a5e42be3c53b1415
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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