HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol → 3-((Dimethylamino)methyl)pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol | HCID 14578455 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-((Dimethylamino)methyl)pyrrolidin-3-ol | HCID 14578459 | — |
Reaction Steps
9.4 g (39 mmol) of 1-benzyl-3-dimethylaminomethyl-3-hydroxypyrrolidine in 60 ml of methanol are hydrogenated using 2 g of palladium/active carbon (5%) at 100° C. and 90 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05284842 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-583891d993f14894a5e42be3c53b1415 |
| Source note | uspto-grants-1994_02 |