1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 14578482, compound

HRID 1974890Notes

Reaction equation

HRID 1974890 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.Cl.Cl.[CH:23]1([NH:26][CH2:27][C:28]2([OH:33])[CH2:32][CH2:31][NH:30][CH2:29]2)[CH2:25][CH2:24]1>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:16])=[C:11]([N:30]4[CH2:31][CH2:32][C:28]([CH2:27][NH:26][CH:23]5[CH2:24][CH2:25]5)([OH:33])[CH2:29]4)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 19382179HCID 19382179, compound

Product 1

HCID 14578482HCID 14578482, compound

Procedure

1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted analogously to Example 6 with 3-cyclopropylaminomethyl-3-hydroxypyrrolidine dihydrochloride to give 1-cyclopropyl-7-(3-cyclopropylaminomethyl-3-hydroxy-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid of melting point 161°-162° (with decomposition).

Sources & evidence

ORD record
ord-ea171a236f0d446bbff167d9e3d79a5e
Source dataset
uspto-grants-1994_02
Patent number
US05284842

Reaction notes

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