2-Aminopyridine → HCID 131718335, compound

HRID 1974923Notes

Reaction equation

HRID 1974923 reaction equation
[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:14]([OH:16])=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[NH:1]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C@H:2]([C:14]([OH:16])=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[NH-:24]

Participants

5

Reactant 3

HCID 104392-AminopyridineHCID 757711-HydroxybenzotriazoleHCID 1581888N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl ester

Product 1

HCID 131718335HCID 131718335, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Boc-L-Asp(OBzl)-OH (1.0 g), 2-aminopyridine (0.35 g), HOBT (0.50 g), WSCD (0.71 g) and DMF (20 ml) were reacted in a similar manner to that of Preparation 1-1) to give Boc-L-Asp(OBzl)-2-pyridylamide.

Workup

  1. customof Preparation 1-1)

Sources & evidence

ORD record
ord-e4740a30a58b498a9a54fb629749386b
Source dataset
uspto-grants-1994_02
Patent number
US05284828

Reaction notes

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