反应详情

To a stirred solution of 2.00 g of 2-butyl-1,4-dihydro-4-oxo-6-quinazolinecarboxaldehyde in 100 ml of tetrahydrofuran, cooled at 0° C., is added 13.0 ml of 2.0 M phenyllithium and stirring continued for 1 hour. The cooling is removed and the reaction allowed to reach room temperature followed by an additional 30 minutes at room temperature. The reaction is diluted with saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer is dried, evaporated to a residue, which is purified by chromatography on silica gel by elution with 0.25:100 methanol-chloroform to give 0.932 g of the desired product. CI MASS SPEC 309(MH

1. customThe cooling is removed
2. customto reach room temperature
3. waitfollowed by an additional 30 minutes at room temperature
4. additionThe reaction is diluted with saturated ammonium chloride solution
5. extractionextracted with ethyl acetate
6. customThe organic layer is dried
7. customevaporated to a residue, which
8. customis purified by chromatography on silica gel by elution with 0.25:100 methanol-chloroform