HCID 19100956, compound → HCID 19100947, compound

HRID 1975007Notes

Reaction equation

HRID 1975007 reaction equation
C([N:8]1[CH:15]([CH3:16])[CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:15]1[CH2:14][CH:13]2[CH:9]([CH2:10][N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]2)[NH:8]1

Participants

4

Reactant 1

HCID 19100956HCID 19100956, compound

Product 1

HCID 19100947HCID 19100947, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

32 g (0.11 mol) of ethyl 2-benzyl-3-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 560 ml of ethanol are hydrogenated on 4.5 g of palladium/active carbon at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-32243b3da3694e8fb1e0cc80261e3ae3
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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