Allylamine → HCID 19100951, compound

HRID 1975010Notes

Reaction equation

HRID 1975010 reaction equation
[CH3:1][O:2][CH:3]([O:7][CH3:8])[C:4]([CH3:6])=O.[CH2:9]([NH2:12])[CH:10]=[CH2:11].[BH4-].[Na+]>C(O)C>[CH2:9]([NH:12][CH:4]([CH3:6])[CH:3]([O:7][CH3:8])[O:2][CH3:1])[CH:10]=[CH2:11]

Participants

5

Reactant 3

HCID 7853AllylamineHCID 80650Pyruvic aldehyde dimethyl acetalHCID 4311764Sodium borohydride

Product 1

HCID 19100951HCID 19100951, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

20 g of molecular sieve are added to 12 g (0.1 mol) of 1,1-dimethoxyacetone in 100 ml of ethanol, and 7 g (0. 12 mol) of allylamine are then added dropwise. The mixture is allowed to stand overnight at room temperature, the liquid phase is decanted off from the molecular sieve and cooled to 0° C. in an ice-bath, and 4 g (0.1 mol) of sodium borohydride are added in small portions. The mixture is stirred overnight at room temperature, concentrated and taken up in 100 ml of water, and this mixture is saturated with potassium carbonate and extracted five times using 100 ml portions of chloroform. The extracts are dried over potassium carbonate, concentrated and distilled.

Workup

  1. additionare then added dropwise
  2. customthe liquid phase is decanted off from the molecular sieve
  3. concentrationconcentrated
  4. extractionextracted five times
  5. dry with materialThe extracts are dried over potassium carbonate
  6. concentrationconcentrated
  7. distillationdistilled

Sources & evidence

ORD record
ord-ec4f3b8af383426c9583488351581ccc
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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