反应详情

16.9 g (79.6 mol) of ethyl 2,8-dimethyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 130 ml of concentrated hydrochloric acid are refluxed overnight. The mixture is concentrated, the concentrate is taken up in 50 ml of water, and this mixture is rendered alkaline using potassium carbonate and extracted five times using 50 ml portions of chloroform. The extracts are dried over potassium carbonate and concentrated, and the residue is distilled.

1. concentrationThe mixture is concentrated
2. extractionextracted five times
3. dry with materialThe extracts are dried over potassium carbonate
4. concentrationconcentrated
5. distillationthe residue is distilled