1-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole → 5-Methyl-octahydropyrrolo(3,4-b)pyrrole

HRID 1975019Notes

Reaction equation

HRID 1975019 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH2:10][CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1

Participants

4

Reactant 1

HCID 191009621-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole

Product 1

HCID 162288995-Methyl-octahydropyrrolo(3,4-b)pyrrole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10.3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7-diazabicyclo(3.3.0]octane in 200 ml of ethanol are hydrogenated on 2.5 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-5f5dbde6bc2445e8ba8c306010fc8159
Source dataset
uspto-grants-1994_02
Patent number
US05284855

Reaction notes

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