反应详情

16 g (55 mmol) of ethyl 2-benzyl-8-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate are refluxed overnight with 50 ml of concentrated hydrochloric acid. The batch is concentrated and dissolved in 50 ml of water, and the mixture is rendered alkaline using potassium carbonate. The mixture is extracted five times using 50 ml portions of chloroform, the extracts are dried over K2CO3 and concentrated, and the residue is distilled.

1. concentrationThe batch is concentrated
2. dissolutiondissolved in 50 ml of water
3. extractionThe mixture is extracted five times
4. dry with materialthe extracts are dried over K2CO3
5. concentrationconcentrated
6. distillationthe residue is distilled