Water → HCID 2883188, compound

HRID 1975255Notes

Reaction equation

HRID 1975255 reaction equation
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH2:12]([NH2:18])[CH:13]1[O:17][CH2:16][CH2:15][CH2:14]1.O.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[CH2:12]([N:18]1[C:1](=[O:11])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]2[C:4]1=[O:6])[CH:13]1[O:17][CH2:16][CH2:15][CH2:14]1

Participants

6

Reactant 4

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 253298TetrahydrofurfurylamineHCID 516892Sodium Bicarbonate

Product 1

HCID 2883188HCID 2883188, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

19.8 g (134 mmol) of phthalic anhydride were dissolved in 500 ml of chloroform. To the resultant solution, 10 g (99 mmol) of tetrahydrofurfurylamine were added with stirring. The resultant mixture was subjected to a reflux overnight while the reactant water yielded was distilled off. The thus obtained reaction mixture was allowed to cool and then was poured into 300 ml of aqueous solution of saturated sodium hydrogencarbonate. Thereafter, an organic solvent layer was separated from the reaction mixture. The residual water layer was subjected to an extraction twice with chloroform and the extract thus obtained was combined with the organic solvent layer which was previously separated.

Workup

  1. customyielded
  2. distillationwas distilled off
  3. customThe thus obtained reaction mixture
  4. temperatureto cool
  5. customThereafter, an organic solvent layer was separated from the reaction mixture
  6. extractionThe residual water layer was subjected to an extraction twice with chloroform
  7. extractionthe extract thus
  8. customobtained
  9. customwas previously separated

Sources & evidence

ORD record
ord-90d9a8a3c21945a2906390d18e5b4c45
Source dataset
uspto-grants-1994_02
Patent number
US05284973

Reaction notes

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