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HRID1975294

反应详情

EQUATION

反应方程式

HRID 1975294 的结构方程式

REACTANTS

反应物

3
结构：O=[Si]=O
HCID24261

Silica

O2Si

结构：COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1.Cl
HCID62920

Diltiazem hydrochloride

C22H27ClN2O4S

2 次

结构：O=C(O)/C=C/C(=O)O
HCID444972

Fumaric acid

C4H4O4

PRODUCTS

生成物

1
结构：COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1
HCID39186

(+)-Diltiazem

C22H26N2O4S

PROCEDURE

实验过程

To an 80 cubic foot blender is charged 188.0 kg of diltiazem HCl, 94.0 kg of fumaric acid NF, 94.0 kg of talc, 2.8 kg of silicon dioxide, and an additional 188.0 kg of diltiazem HCl. The mixture is dry blended for 15 minutes and then milled through a 0.013 inch screen using a conventional milling machine to a sufficiently fine particle size, averaging about 75 microns.

WORKUP

后处理

  1. customThe mixture is dry blended for 15 minutes
  2. custommilled through a 0.013 inch screen