Silica → Diltiazem

HRID 1975294Notes

Reaction equation

HRID 1975294 reaction equation
[CH3:1][C:2]([O:4][C@H:5]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[S:7][C@H:6]1[C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)=[O:3].Cl.C(O)(=O)/C=C/C(O)=O.[Si](=O)=O>>[CH3:1][C:2]([O:4][C@H:5]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[S:7][C@H:6]1[C:22]1[CH:23]=[CH:24][C:25]([O:28][CH3:29])=[CH:26][CH:27]=1)=[O:3]

Participants

4

Reactant 3

HCID 24261SilicaHCID 62920Diltiazem Hydrochloride2×HCID 444972Fumaric Acid

Product 1

HCID 39186Diltiazem

Procedure

To an 80 cubic foot blender is charged 188.0 kg of diltiazem HCl, 94.0 kg of fumaric acid NF, 94.0 kg of talc, 2.8 kg of silicon dioxide, and an additional 188.0 kg of diltiazem HCl. The mixture is dry blended for 15 minutes and then milled through a 0.013 inch screen using a conventional milling machine to a sufficiently fine particle size, averaging about 75 microns.

Workup

  1. customThe mixture is dry blended for 15 minutes
  2. custommilled through a 0.013 inch screen

Sources & evidence

ORD record
ord-075568731bba443dab0ec17170a67815
Source dataset
uspto-grants-1994_02
Patent number
US05286497

Reaction notes

Loading…