HuagongsheHuagongshe Chemistry Print Report · For research reference only
Silica → Diltiazem
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Silica | HCID 24261 | — |
| Reactant | Diltiazem Hydrochloride | HCID 62920 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Product | Diltiazem | HCID 39186 | — |
Reaction Steps
To an 80 cubic foot blender is charged 188.0 kg of diltiazem HCl, 94.0 kg of fumaric acid NF, 94.0 kg of talc, 2.8 kg of silicon dioxide, and an additional 188.0 kg of diltiazem HCl. The mixture is dry blended for 15 minutes and then milled through a 0.013 inch screen using a conventional milling machine to a sufficiently fine particle size, averaging about 75 microns.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286497 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-075568731bba443dab0ec17170a67815 |
| Source note | uspto-grants-1994_02 |