Hydrochloric Acid → HCID 18655319, compound

HRID 1975299Notes

Reaction equation

HRID 1975299 reaction equation
[CH:1](=[C:5]1/[C:6]([O:11]C)=[CH:7][C:8](=[O:10])[NH:9]/1)\[CH:2]([CH3:4])[CH3:3].Cl>[OH-].[Na+]>[CH:1](=[C:5]1/[C:6](=[O:11])[CH2:7][C:8](=[O:10])[NH:9]/1)\[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10986637HCID 10986637, compound

Product 1

HCID 18655319HCID 18655319, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

50 g of finely powdered (Z)-5-isobutylidene-4-methoxy-3-pyrroline-2-one was stirred with 500 ml of concentrated hydrochloric acid for 5 hours at room temperature. The mixture was then stirred 5 hours at room temperature and slowly mixed with 1 liter of 14 percent sodium hydroxide solution. The precipitated yellow product was filtered off, washed with cold water and dried in a vacuum drying cabinet. The yield of the title compound was 42.0 g (92 percent of theory). The title compound had a melting point of 134° to 136° C. (THF/hexane).

Workup

  1. filtrationThe precipitated yellow product was filtered off
  2. washwashed with cold water
  3. customdried in a vacuum
  4. customdrying cabinet

Sources & evidence

ORD record
ord-74a555775e714813869f6184bb2a79f9
Source dataset
uspto-grants-1994_02
Patent number
US05286650

Reaction notes

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