HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylamino)benzoic acid → 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylamino)benzoic acid | HCID 66345 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-{2-[4-(Methylsulfanyl)phenyl]ethyl}piperazine | HCID 53859945 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine | HCID 54117481 | — |
Reaction Steps
The 1-(4-methylaminobenzoyl)-4-[2-(4-methylmercaptophenyl)ethyl]piperazine is prepared from 1.66 g of 4-methylaminobenzoic acid, 1.95 g of N,N-carbonyldiimidazole and 2.35 g of 1-[2-(4-methylmercaptophenyl)ethyl]piperazine in dimethylformamide at 85°. The base is purified via the hydrochloride (m.p. 185°, decomp.) and melts at 120°-121°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-225fc4c915684fd68275fc99b7a4c063 |
| Source note | uspto-grants-1994_02 |