HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-[4-(3-Chloropropionylamino)benzoyl]-4-[2-(4-chlorophenyl)-ethyl]piperazine | HCID 19099469 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(4-Acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 19099428 | — |
Reaction Steps
0.5 g of 1-[4-(3-chloropropionylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine and 0.4 g of triethylamine are dissolved in 20 ml of methylene chloride, and the solution is boiled under reflux for 4 hours and then concentrated by evaporation, yielding 1-(4-acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine having a melting point of 163°-165°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-8b307399d1bc46c6999229a8f9a77aa2 |
| Source note | uspto-grants-1994_02 |