Triethylamine → 1-(4-Acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine

HRID 1975357Notes

Reaction equation

HRID 1975357 reaction equation
Cl[CH2:2][CH2:3][C:4]([NH:6][C:7]1[CH:29]=[CH:28][C:10]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:15][CH2:14]2)=[O:12])=[CH:9][CH:8]=1)=[O:5].C(N(CC)CC)C>C(Cl)Cl>[C:4]([NH:6][C:7]1[CH:29]=[CH:28][C:10]([C:11]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[CH2:17][CH2:18]2)=[O:12])=[CH:9][CH:8]=1)(=[O:5])[CH:3]=[CH2:2]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 190994691-[4-(3-Chloropropionylamino)benzoyl]-4-[2-(4-chlorophenyl)-ethyl]piperazine

Product 1

HCID 190994281-(4-Acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 g of 1-[4-(3-chloropropionylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]-piperazine and 0.4 g of triethylamine are dissolved in 20 ml of methylene chloride, and the solution is boiled under reflux for 4 hours and then concentrated by evaporation, yielding 1-(4-acryloylaminobenzoyl)-4-[2-(4-chlorophenyl)ethyl]piperazine having a melting point of 163°-165°.

Workup

  1. temperatureunder reflux for 4 hours
  2. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-8b307399d1bc46c6999229a8f9a77aa2
Source dataset
uspto-grants-1994_02
Patent number
US05286728

Reaction notes

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