1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Reaction equation
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:15]1[CH:37]=[CH:36][C:18]([C:19]([N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[CH2:23][CH2:22]2)=[O:20])=[CH:17][CH:16]=1)C(C(OC)=O)=O)([CH3:4])[CH3:3].[Cl-].COC(=O)C(O)=O>>[CH:2]([O:5][CH2:6][CH2:7][NH:8][C:15]1[CH:37]=[CH:36][C:18]([C:19]([N:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=3)[CH2:25][CH2:26]2)=[O:20])=[CH:17][CH:16]=1)([CH3:4])[CH3:3]Participants
3
Procedure
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 152°-154° is obtained from 3 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine by reaction with oxalic acid monomethyl ester chloride.
Sources & evidence
- ORD record
- ord-eaf7edbb8bda49a8becc320063ccf9c7
- Source dataset
- uspto-grants-1994_02
- Patent number
- US05286728
Reaction notes
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