HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride | HCID 19099446 | — |
| Reactant | Oxalic acid monomethyl ester chloride | HCID 86640482 | — |
| Product | 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 9845547 | — |
Reaction Steps
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylcarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 152°-154° is obtained from 3 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine by reaction with oxalic acid monomethyl ester chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-eaf7edbb8bda49a8becc320063ccf9c7 |
| Source note | uspto-grants-1994_02 |