反应详情

In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 77°-79° is obtained from 1 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 1) by reaction with malonic acid monomethyl ester chloride.