1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Reaction equation
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:16]1[CH:38]=[CH:37][C:19]([C:20]([N:22]2[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:18][CH:17]=1)C(=O)CC(OC)=O)([CH3:4])[CH3:3].[Cl-].COC(=O)CC(O)=O>>[CH:2]([O:5][CH2:6][CH2:7][NH:8][C:16]1[CH:38]=[CH:37][C:19]([C:20]([N:22]2[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:26][CH2:27]2)=[O:21])=[CH:18][CH:17]=1)([CH3:4])[CH3:3]Participants
3
Procedure
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 77°-79° is obtained from 1 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 1) by reaction with malonic acid monomethyl ester chloride.
Sources & evidence
- ORD record
- ord-a5dacfd1859e46bfb158d3e6a4ffa529
- Source dataset
- uspto-grants-1994_02
- Patent number
- US05286728
Reaction notes
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