HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride | HCID 19099532 | — |
| Reactant | Malonic acid methylester chloride | HCID 86615040 | — |
| Product | 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine | HCID 9845547 | — |
Reaction Steps
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-methoxycarbonylacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 77°-79° is obtained from 1 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 1) by reaction with malonic acid monomethyl ester chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05286728 |
| Source dataset | uspto-grants-1994_02 |
| ORD ID | ord-a5dacfd1859e46bfb158d3e6a4ffa529 |
| Source note | uspto-grants-1994_02 |