反应详情

65 ml of trifluoroacetic acid are introduced into 100 ml of dichloromethane. A solution of 7.2 g of 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine is added thereto within a period of 5 minutes. After 2 hours at RT, the reaction solution is concentrated by evaporation and the residue is neutralised with sodium hydroxide solution and extracted with ether. Concentration by evaporation and treatment with ethereal hydrochloric acid yield 1-[3-(2-isopropyloxyethylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 157°-159°.

1. waitAfter 2 hours at RT
2. concentrationthe reaction solution is concentrated by evaporation
3. extractionextracted with ether
4. concentrationConcentration
5. customby evaporation and treatment with ethereal hydrochloric acid