HRID1975374

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

HCID19099443

未命名化合物

结构：CC(C)(C)OC(=O)Nc1cccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)c1

HCID19099463

未命名化合物

PRODUCTS

生成物

结构：CC(C)OCCN(C(=O)OC(C)(C)C)c1cccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)c1

HCID19099472

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

6 g of 1-[3-(N-tert-butyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine and 4.18 g of 2-isopropyloxyethyl p-toluenesulfonate are reacted in DMSO in the presence of 1.01 g of finely powdered KOH. The oily 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine so obtained is reacted further directly.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-95798e9f98044af386dcd00cea929716
来源数据集: uspto-grants-1994_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05286728
来源说明: uspto-grants-1994_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:29]=[CH:30][CH:31]=1)[C:12]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH2:16][CH2:15]1)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC(S(O[CH2:42][CH2:43][O:44][CH:45]([CH3:47])[CH3:46])(=O)=O)=CC=1.[OH-].[K+]>CS(C)=O>[CH:45]([O:44][CH2:43][CH2:42][N:8]([C:9]1[CH:10]=[C:11]([CH:29]=[CH:30][CH:31]=1)[C:12]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)[CH2:16][CH2:15]1)=[O:13])[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])([CH3:47])[CH3:46]