Potassium Hydroxide → 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

HRID 1975374Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1975374
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:29]=[CH:30][CH:31]=1)[C:12]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH2:16][CH2:15]1)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC(S(O[CH2:42][CH2:43][O:44][CH:45]([CH3:47])[CH3:46])(=O)=O)=CC=1.[OH-].[K+]>CS(C)=O>[CH:45]([O:44][CH2:43][CH2:42][N:8]([C:9]1[CH:10]=[C:11]([CH:29]=[CH:30][CH:31]=1)[C:12]([N:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=2)[CH2:16][CH2:15]1)=[O:13])[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])([CH3:47])[CH3:46]

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 190994432-Isopropoxyethyl 4-methylbenzenesulfonateHCID 190994631-[3-(N-tert-butyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine

Produkt 1

HCID 190994721-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

6 g of 1-[3-(N-tert-butyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine and 4.18 g of 2-isopropyloxyethyl p-toluenesulfonate are reacted in DMSO in the presence of 1.01 g of finely powdered KOH. The oily 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine so obtained is reacted further directly.

Quellen und Nachweise

ORD-Eintrag
ord-95798e9f98044af386dcd00cea929716
Quelldatensatz
uspto-grants-1994_02
Patentnummer
US05286728

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