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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1975374Generated: October 25, 2026

Potassium Hydroxide → 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

https://huagongshe.com/reaction/1975374

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
Reactant2-Isopropoxyethyl 4-methylbenzenesulfonateHCID 19099443—
Reactant1-[3-(N-tert-butyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazineHCID 19099463—
SolventDimethyl SulfoxideHCID 679—
Product1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazineHCID 19099472—

Reaction Steps

6 g of 1-[3-(N-tert-butyloxycarbonylamino)benzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine and 4.18 g of 2-isopropyloxyethyl p-toluenesulfonate are reacted in DMSO in the presence of 1.01 g of finely powdered KOH. The oily 1-{3-[N-(2-isopropyloxyethyl)-N-tert-butoxycarbonylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine so obtained is reacted further directly.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05286728
Source datasetuspto-grants-1994_02
ORD IDord-95798e9f98044af386dcd00cea929716
Source noteuspto-grants-1994_02