1-(2-Methylbenzyl)piperazine → HCID 19099445, compound

HRID 1975383Notes

Reaction equation

HRID 1975383 reaction equation
[CH:1]([O:4][CH2:5][CH2:6][N:7]([C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1)[C:8](=[O:11])[CH2:9][Cl:10])([CH3:3])[CH3:2].[CH3:21][C:22]1[CH:34]=[CH:33][CH:32]=[CH:31][C:23]=1[CH2:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH:1]([O:4][CH2:5][CH2:6][N:7]([C:12]1[CH:20]=[CH:19][C:15]([C:16]([N:28]2[CH2:29][CH2:30][N:25]([CH2:24][C:23]3[CH:31]=[CH:32][CH:33]=[CH:34][C:22]=3[CH3:21])[CH2:26][CH2:27]2)=[O:17])=[CH:14][CH:13]=1)[C:8](=[O:11])[CH2:9][Cl:10])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 792121-(2-Methylbenzyl)piperazineHCID 190994164-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride

Product 1

HCID 19099445HCID 19099445, compound

Procedure

Analogously to Example 55, 1.5 g of 4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl chloride are reacted with 0.76 g of 2-methylbenzylpiperazine, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-(2-methylbenzyl)piperazine. The hydrochloride thereof melts at 142°-143°.

Sources & evidence

ORD record
ord-447d6f5c565c41e38004ca27f4f2976f
Source dataset
uspto-grants-1994_02
Patent number
US05286728

Reaction notes

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