Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1975385Generated: October 31, 2026

Piperidine → 1-{4-[N-(2-isopropyloxyethyl)-N-piperidinoacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

https://huagongshe.com/reaction/1975385

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidineHCID 8082—
Reactant1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine fumarateHCID 19099464—
Product1-{4-[N-(2-isopropyloxyethyl)-N-piperidinoacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazineHCID 54083906—

Reaction Steps

Analogously to Example 51, 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 3) and piperidine are reacted, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-piperidinoacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine. The difumarate thereof melts at 179°-180°.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05286728
Source datasetuspto-grants-1994_02
ORD IDord-50c17726b0e44d48b34eda167c14ddd8
Source noteuspto-grants-1994_02