Piperidine → 1-{4-[N-(2-isopropyloxyethyl)-N-piperidinoacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine
Reaction equation
C(O)(=O)/C=C/C(O)=O.[CH:9]([O:12][CH2:13][CH2:14][N:15]([C:20]1[CH:42]=[CH:41][C:23]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][C:34]3[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=3)[CH2:28][CH2:27]2)=[O:25])=[CH:22][CH:21]=1)[C:16](=[O:19])[CH2:17]Cl)([CH3:11])[CH3:10].[NH:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1>>[CH:9]([O:12][CH2:13][CH2:14][N:15]([C:20]1[CH:42]=[CH:41][C:23]([C:24]([N:26]2[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][C:34]3[CH:35]=[CH:36][C:37]([Cl:40])=[CH:38][CH:39]=3)[CH2:28][CH2:27]2)=[O:25])=[CH:22][CH:21]=1)[C:16](=[O:19])[CH2:17][N:43]1[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]1)([CH3:10])[CH3:11]Participants
3
Procedure
Analogously to Example 51, 1-{4-[N-(2-isopropyloxyethyl)-N-chloroacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 3) and piperidine are reacted, yielding 1-{4-[N-(2-isopropyloxyethyl)-N-piperidinoacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine. The difumarate thereof melts at 179°-180°.
Sources & evidence
- ORD record
- ord-50c17726b0e44d48b34eda167c14ddd8
- Source dataset
- uspto-grants-1994_02
- Patent number
- US05286728
Reaction notes
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